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IJDMB
2011
129views more  IJDMB 2011»
12 years 11 months ago
Modelling gene and protein regulatory networks with Answer Set Programming
: Recently, many approaches to model regulatory networks have been proposed in the systems biology domain, however the task is far from being solved. In this paper we propose an an...
Timur Fayruzov, Jeroen Janssen, Dirk Vermeir, Chri...
SAC
2008
ACM
13 years 7 months ago
Bayesian inference for a discretely observed stochastic kinetic model
The ability to infer parameters of gene regulatory networks is emerging as a key problem in systems biology. The biochemical data are intrinsically stochastic and tend to be observ...
Richard J. Boys, Darren J. Wilkinson, Thomas B. L....
BMCBI
2007
197views more  BMCBI 2007»
13 years 8 months ago
Boolean networks using the chi-square test for inferring large-scale gene regulatory networks
Background: Boolean network (BN) modeling is a commonly used method for constructing gene regulatory networks from time series microarray data. However, its major drawback is that...
Haseong Kim, Jae K. Lee, Taesung Park
GECCO
2006
Springer
220views Optimization» more  GECCO 2006»
13 years 11 months ago
Comparing evolutionary algorithms on the problem of network inference
In this paper, we address the problem of finding gene regulatory networks from experimental DNA microarray data. We focus on the evaluation of the performance of different evoluti...
Christian Spieth, Rene Worzischek, Felix Streicher...
BMCBI
2005
97views more  BMCBI 2005»
13 years 7 months ago
Phylogenetic reconstruction of ancestral character states for gene expression and mRNA splicing data
Background: As genomes evolve after speciation, gene content, coding sequence, gene expression, and splicing all diverge with time from ancestors with close relatives. A minimum e...
Roald Rossnes, Ingvar Eidhammer, David A. Liberles