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IMSCCS
2006
IEEE
15 years 11 months ago
Combining Comparative Genomics with de novo Motif Discovery to Identify Human Transcription Factor DNA-Binding Motifs
Background: As more and more genomes are sequenced, comparative genomics approaches provide a methodology for identifying conserved regulatory elements that may be involved in gen...
Linyong Mao, W. Jim Zheng
CISIS
2010
IEEE
16 years 18 days ago
Gene Ontology Rewritten for Computing Gene Functional Similarity
Abstract—Discovery biological organisation of the cell in modules network is a challenging task. Currently, approaches based on a controlled vocabulary, as Gene Ontology, to iden...
Alessia Visconti, Francesca Cordero, Marco Botta, ...
BMCBI
2007
106views more  BMCBI 2007»
15 years 5 months ago
In silico identification of NF-kappaB-regulated genes in pancreatic beta-cells
Background: Pancreatic beta-cells are the target of an autoimmune attack in type 1 diabetes mellitus (T1DM). This is mediated in part by cytokines, such as interleukin (IL)-1β an...
Najib Naamane, Jacques van Helden, Decio L. Eiziri...
CIBCB
2005
IEEE
15 years 11 months ago
Network Motifs, Feedback Loops and the Dynamics of Genetic Regulatory Networks
We analyse a suite of Boolean networks which have been evolved to exhibit limit cycle-type dynamics in terms of the distribution of small network motifs and feedback loops. We find...
Jennifer Hallinan, Paul T. Jackway
BMCBI
2007
148views more  BMCBI 2007»
15 years 5 months ago
fREDUCE: Detection of degenerate regulatory elements using correlation with expression
Background: The precision of transcriptional regulation is made possible by the specificity of physical interactions between transcription factors and their cognate binding sites ...
Randy Z. Wu, Christina Chaivorapol, Jiashun Zheng,...