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BMCBI
2010
154views more  BMCBI 2010»
13 years 8 months ago
Candidate gene prioritization by network analysis of differential expression using machine learning approaches
Background: Discovering novel disease genes is still challenging for diseases for which no prior knowledge - such as known disease genes or disease-related pathways - is available...
Daniela Nitsch, Joana P. Gonçalves, Fabian ...
BMCBI
2006
239views more  BMCBI 2006»
13 years 8 months ago
Applying dynamic Bayesian networks to perturbed gene expression data
Background: A central goal of molecular biology is to understand the regulatory mechanisms of gene transcription and protein synthesis. Because of their solid basis in statistics,...
Norbert Dojer, Anna Gambin, Andrzej Mizera, Bartek...
RECOMB
2004
Springer
14 years 8 months ago
Modeling and Analysis of Heterogeneous Regulation in Biological Networks
Abstract. In this study we propose a novel model for the representation of biological networks and provide algorithms for learning model parameters from experimental data. Our appr...
Irit Gat-Viks, Amos Tanay, Ron Shamir
NAR
2002
141views more  NAR 2002»
13 years 7 months ago
Co-expression pattern from DNA microarray experiments as a tool for operon prediction
The prediction of operons, the smallest unit of transcription in prokaryotes, is the first step towards reconstruction of a regulatory network at the whole genome level. Sequence ...
Chiara Sabatti, Lars Rohlin, Min-Kyu Oh, James C. ...
COCOON
2005
Springer
14 years 1 months ago
Quartet-Based Phylogeny Reconstruction from Gene Orders
Abstract. Phylogenetic reconstruction from gene-rearrangement data is attracting increasing attention from biologists and computer scientists. Methods used in reconstruction includ...
Tao Liu, Jijun Tang, Bernard M. E. Moret