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BMCBI
2010
116views more  BMCBI 2010»
13 years 8 months ago
Optimization algorithms for functional deimmunization of therapeutic proteins
Background: To develop protein therapeutics from exogenous sources, it is necessary to mitigate the risks of eliciting an anti-biotherapeutic immune response. A key aspect of the ...
Andrew S. Parker, Wei Zheng, Karl E. Griswold, Chr...
ICPR
2008
IEEE
14 years 3 months ago
Gene function prediction using protein domain probability and hierarchical Gene Ontology information
The Gene Ontology (GO) is a controlled vocabulary of terms to describe protein functions. It also includes a hierarchical description of the relationships among the terms in the f...
Jaehee Jung, Michael R. Thon
BMCBI
2006
112views more  BMCBI 2006»
13 years 8 months ago
Protein disorder prediction by condensed PSSM considering propensity for order or disorder
Background: More and more disordered regions have been discovered in protein sequences, and many of them are found to be functionally significant. Previous studies reveal that dis...
Chung-Tsai Su, Chien-Yu Chen, Yu-Yen Ou
BMCBI
2007
142views more  BMCBI 2007»
13 years 8 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2008
145views more  BMCBI 2008»
13 years 8 months ago
The contrasting properties of conservation and correlated phylogeny in protein functional residue prediction
Background: Amino acids responsible for structure, core function or specificity may be inferred from multiple protein sequence alignments where a limited set of residue types are ...
Jonathan R. Manning, Emily R. Jefferson, Geoffrey ...