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BMCBI
2008
155views more  BMCBI 2008»
13 years 7 months ago
AMMOS: Automated Molecular Mechanics Optimization tool for in silico Screening
Background: Virtual or in silico ligand screening combined with other computational methods is one of the most promising methods to search for new lead compounds, thereby greatly ...
Tania Pencheva, David Lagorce, Ilza Pajeva, Bruno ...
BCB
2010
140views Bioinformatics» more  BCB 2010»
13 years 2 months ago
Guiding belief propagation using domain knowledge for protein-structure determination
A major bottleneck in high-throughput protein crystallography is producing protein-structure models from an electrondensity map. In previous work, we developed Acmi, a probabilist...
Ameet Soni, Craig A. Bingman, Jude W. Shavlik
IEEEPACT
2009
IEEE
14 years 2 months ago
Soft-OLP: Improving Hardware Cache Performance through Software-Controlled Object-Level Partitioning
—Performance degradation of memory-intensive programs caused by the LRU policy’s inability to handle weaklocality data accesses in the last level cache is increasingly serious ...
Qingda Lu, Jiang Lin, Xiaoning Ding, Zhao Zhang, X...
BMCBI
2006
116views more  BMCBI 2006»
13 years 7 months ago
Optimized mixed Markov models for motif identification
Background: Identifying functional elements, such as transcriptional factor binding sites, is a fundamental step in reconstructing gene regulatory networks and remains a challengi...
Weichun Huang, David M. Umbach, Uwe Ohler, Leping ...
ICCS
2005
Springer
14 years 1 months ago
A Computational Model of Micro-vascular Growth
In order to supply a growing tissue with oxygen and nutrients and to remove its metabolic wastes, blood vessels penetrating the tissue are formed. Multiple mechanisms are involved ...
Dominik Szczerba, Gábor Székely