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    BMCBI
    2008
    144views more  BMCBI 2008»
    Local conservation scores without a priori assumptions on neutral substitution rates
    13 years 11 months ago
    Local conservation scores without a priori assumptions on neutral substitution rates
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    Background: Comparative genomics aims to detect signals of evolutionary conservation as an indicator of functional constraint. Surprisingly, results of the ENCODE project revealed...
    Janis Dingel, Pavol Hanus, Niccolò Leonardi...
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    BMCBI
    2007
    99views more  BMCBI 2007»
    Orthogonal projections to latent structures as a strategy for microarray data normalization
    13 years 11 months ago
    Orthogonal projections to latent structures as a strategy for microarray data normalization
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    Background: During generation of microarray data, various forms of systematic biases are frequently introduced which limits accuracy and precision of the results. In order to prop...
    Max Bylesjö, Daniel Eriksson, Andreas Sjö...
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    BMCBI
    2007
    169views more  BMCBI 2007»
    Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and i
    13 years 11 months ago
    Transcriptional regulatory network refinement and quantification through kinetic modeling, gene expression microarray data and i
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    Background: Gene expression microarray and other multiplex data hold promise for addressing the challenges of cellular complexity, refined diagnoses and the discovery of well-targ...
    Abdallah Sayyed-Ahmad, Kagan Tuncay, Peter J. Orto...
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    BMCBI
    2006
    101views more  BMCBI 2006»
    SuperMimic - Fitting peptide mimetics into protein structures
    13 years 11 months ago
    SuperMimic - Fitting peptide mimetics into protein structures
    Download  bioinformatics.charite.de
    Background: Various experimental techniques yield peptides that are biologically active but have unfavourable pharmacological properties. The design of structurally similar organi...
    Andrean Goede, Elke Michalsky, Ulrike Schmidt, Rob...
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    BMCBI
    2006
    240views more  BMCBI 2006»
    Statistical analysis of real-time PCR data
    13 years 11 months ago
    Statistical analysis of real-time PCR data
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    Background: Even though real-time PCR has been broadly applied in biomedical sciences, data processing procedures for the analysis of quantitative real-time PCR are still lacking;...
    Joshua S. Yuan, Ann Reed, Feng Chen, C. Neal Stewa...
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