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BMCBI
2011
13 years 2 months ago
Tiling array data analysis: a multiscale approach using wavelets
Background: Tiling array data is hard to interpret due to noise. The wavelet transformation is a widely used technique in signal processing for elucidating the true signal from no...
Alexander Karpikov, Joel S. Rozowsky, Mark Gerstei...
ICML
2008
IEEE
14 years 8 months ago
Expectation-maximization for sparse and non-negative PCA
We study the problem of finding the dominant eigenvector of the sample covariance matrix, under additional constraints on the vector: a cardinality constraint limits the number of...
Christian D. Sigg, Joachim M. Buhmann
BMCBI
2008
169views more  BMCBI 2008»
13 years 7 months ago
CompMoby: Comparative MobyDick for detection of cis-regulatory motifs
Background: The regulation of gene expression is complex and occurs at many levels, including transcriptional and post-transcriptional, in metazoans. Transcriptional regulation is...
Christina Chaivorapol, Collin Melton, Grace Wei, R...
VLDB
1992
ACM
151views Database» more  VLDB 1992»
13 years 11 months ago
A Uniform Approach to Processing Temporal Queries
Research in temporal databases has mainly focused on defining temporal data models by extending existing models, and developing access structures for temporal data. Little has bee...
Umeshwar Dayal, Gene T. J. Wuu
BMCBI
2007
147views more  BMCBI 2007»
13 years 7 months ago
Predicting combinatorial binding of transcription factors to regulatory elements in the human genome by association rule mining
Background: Cis-acting transcriptional regulatory elements in mammalian genomes typically contain specific combinations of binding sites for various transcription factors. Althoug...
Xochitl C. Morgan, Shulin Ni, Daniel P. Miranker, ...