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» A Study of the Role of Single Node Mutation in Genetic Progr...
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BMCBI
2007
145views more  BMCBI 2007»
13 years 7 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
BMCBI
2010
151views more  BMCBI 2010»
13 years 7 months ago
CCRaVAT and QuTie - enabling analysis of rare variants in large-scale case control and quantitative trait association studies
Background: Genome-wide association studies have been successful in finding common variants influencing common traits. However, these associations only account for a fraction of t...
Robert Lawrence, Aaron G. Day-Williams, Katherine ...
BMCBI
2010
108views more  BMCBI 2010»
13 years 7 months ago
Confronting two-pair primer design for enzyme-free SNP genotyping based on a genetic algorithm
Background: Polymerase chain reaction with confronting two-pair primers (PCR-CTPP) method produces allelespecific DNA bands of different lengths by adding four designed primers an...
Cheng-Hong Yang, Yu-Huei Cheng, Li-Yeh Chuang, Hsu...
GECCO
2006
Springer
161views Optimization» more  GECCO 2006»
13 years 11 months ago
An empirical investigation of how and why neutrality affects evolutionary search
The effects of neutrality on evolutionary search have been considered in a number of interesting studies, the results of which, however, have been contradictory. Some researchers ...
Edgar Galván López, Riccardo Poli