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BMCBI
2006
166views more  BMCBI 2006»
13 years 7 months ago
Extraction of phylogenetic network modules from the metabolic network
Background: In bio-systems, genes, proteins and compounds are related to each other, thus forming complex networks. Although each organism has its individual network, some organis...
Takuji Yamada, Minoru Kanehisa, Susumu Goto
BMCBI
2005
122views more  BMCBI 2005»
13 years 7 months ago
Computational verification of protein-protein interactions by orthologous co-expression
Background: High-throughput methods identify an overwhelming number of protein-protein interactions. However, the limited accuracy of these methods results in the false identifica...
Itay Tirosh, Naama Barkai
BMCBI
2007
130views more  BMCBI 2007»
13 years 7 months ago
A model-based optimization framework for the inference of regulatory interactions using time-course DNA microarray expression da
Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, th...
Reuben Thomas, Carlos J. Paredes, Sanjay Mehrotra,...
BMCBI
2007
144views more  BMCBI 2007»
13 years 7 months ago
InPrePPI: an integrated evaluation method based on genomic context for predicting protein-protein interactions in prokaryotic ge
Background: Although many genomic features have been used in the prediction of proteinprotein interactions (PPIs), frequently only one is used in a computational method. After rea...
Jingchun Sun, Yan Sun, Guohui Ding, Qi Liu, Chuan ...
BMCBI
2005
178views more  BMCBI 2005»
13 years 7 months ago
A quantization method based on threshold optimization for microarray short time series
Background: Reconstructing regulatory networks from gene expression profiles is a challenging problem of functional genomics. In microarray studies the number of samples is often ...
Barbara Di Camillo, Fatima Sanchez-Cabo, Gianna To...