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BIBE
2007
IEEE
138views Bioinformatics» more  BIBE 2007»
14 years 2 months ago
A Flexible Stem-Based Local Search Algorithm for Predicting RNA Secondary Structures Including Pseudoknots
-We demonstrate a new algorithm named FlexStem to predict RNA secondary structures with pseudoknots. Our approach is based on the free energy minimization criterion, and utilizes a...
Xiang Chen, Simin He, Dongbo Bu, Runsheng Chen, We...
ALMOB
2008
124views more  ALMOB 2008»
13 years 7 months ago
A scoring matrix approach to detecting miRNA target sites
Background: Experimental identification of microRNA (miRNA) targets is a difficult and time consuming process. As a consequence several computational prediction methods have been ...
Simon Moxon, Vincent Moulton, Jan T. Kim
BMCBI
2010
113views more  BMCBI 2010»
13 years 7 months ago
Improving performance of mammalian microRNA target prediction
Background: MicroRNAs (miRNAs) are single-stranded non-coding RNAs known to regulate a wide range of cellular processes by silencing the gene expression at the protein and/or mRNA...
Hui Liu, Dong Yue, Yidong Chen, Shou-Jiang Gao, Yu...
BIOCOMP
2006
13 years 9 months ago
An Approach to Selecting Putative RNA Motifs Using MDL Principle
The history of molecular biology is punctuated by a series of discoveries demonstrating the surprising breadth of biological roles of ribonucleic acid (RNA). An ensemble of evoluti...
Mohammad Anwar, Marcel Turcotte
APBC
2004
173views Bioinformatics» more  APBC 2004»
13 years 9 months ago
RNA Secondary Structure Prediction with Simple Pseudoknots
Pseudoknots are widely occurring structural motifs in RNA. Pseudoknots have been shown to be functionally important in different RNAs which play regulatory, catalytic, or structur...
Jitender S. Deogun, Ruben Donts, Olga Komina, Fang...