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» A cross-comparison of a large dataset of genes
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BMCBI
2010
119views more  BMCBI 2010»
13 years 7 months ago
Multi-task learning for cross-platform siRNA efficacy prediction: an in-silico study
Background: Gene silencing using exogenous small interfering RNAs (siRNAs) is now a widespread molecular tool for gene functional study and new-drug target identification. The key...
Qi Liu, Qian Xu, Vincent Wenchen Zheng, Hong Xue, ...
EVOW
2006
Springer
13 years 11 months ago
Hierarchical Clustering, Languages and Cancer
In this paper, we introduce a novel objective function for the hierarchical clustering of data from distance matrices, a very relevant task in Bioinformatics. To test the robustnes...
Pritha Mahata, Wagner Costa, Carlos Cotta, Pablo M...
BIOCOMP
2008
13 years 9 months ago
Discoveries in shRNA Design
-- To successfully apply RNAi, the very first step is to design functional siRNA or shRNA sequences targeting specific genes. Many characteristics of functional synthetic siRNAs ha...
Hong Zhou, Xiao Zeng, Joseph Manthey
BMCBI
2010
125views more  BMCBI 2010»
13 years 7 months ago
In-silico prediction of blood-secretory human proteins using a ranking algorithm
Background: Computational identification of blood-secretory proteins, especially proteins with differentially expressed genes in diseased tissues, can provide highly useful inform...
Qi Liu, Juan Cui, Qiang Yang, Ying Xu
BMCBI
2008
109views more  BMCBI 2008»
13 years 7 months ago
LTRharvest, an efficient and flexible software for de novo detection of LTR retrotransposons
Background: Transposable elements are abundant in eukaryotic genomes and it is believed that they have a significant impact on the evolution of gene and chromosome structure. Whil...
David Ellinghaus, Stefan Kurtz, Ute Willhoeft