Background: A number of methods that use both protein structural and evolutionary information are available to predict the functional consequences of missense mutations. However, ...
Chris J. Needham, James R. Bradford, Andrew J. Bul...
Motivation: Protein–protein complexes are known to play key roles in many cellular processes. However, they are often not accessible to experimental study because of their low s...
Background: Most methods for predicting functional sites in protein 3D structures, rely on information on related proteins and cannot be applied to proteins with no known relative...
Benoit H. Dessailly, Marc F. Lensink, Shoshana J. ...
The intricate intracellular infrastructure of all known life forms is based on proteins. The folded shape of a protein determines both the protein’s function and the set of mole...
G. J. Shawn Tan, Ferran D. Revilla, Klaus-Peter Za...
Abstract. The protein family classification problem, which consists of determining the family memberships of given unknown protein sequences, is very important for a biologist for ...