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JDA
2007
156views more  JDA 2007»
13 years 7 months ago
A linear time algorithm for the inversion median problem in circular bacterial genomes
In the median problem, we are given a distance or dissimilarity measure d, three genomes G1, G2, and G3, and we want to find a genome G (a median) such that the sum 3 i=1 d(G, Gi...
Enno Ohlebusch, Mohamed Ibrahim Abouelhoda, Kathri...
WABI
2001
Springer
112views Bioinformatics» more  WABI 2001»
13 years 12 months ago
Finding an Optimal Inversion Median: Experimental Results
We derive a branch-and-bound algorithm to find an optimal inversion median of three signed permutations. The algorithm prunes to manageable size an extremely large search tree usi...
Adam C. Siepel, Bernard M. E. Moret
BMCBI
2010
95views more  BMCBI 2010»
13 years 7 months ago
Heuristics for the inversion median problem
Background: The study of genome rearrangements has become a mainstay of phylogenetics and comparative genomics. Fundamental in such a study is the median problem: given three geno...
Vaibhav Rajan, Andrew Wei Xu, Yu Lin, Krister M. S...
GCB
2006
Springer
119views Biometrics» more  GCB 2006»
13 years 11 months ago
Comparative Analysis of Cyclic Sequences: Viroids and other Small Circular RNAs
: The analysis of small circular sequences requires specialized tools. While the differences between linear and circular sequences can be neglected in the case of long molecules su...
Axel Mosig, Ivo L. Hofacker, Peter F. Stadler
TCS
2011
13 years 2 months ago
The transposition median problem is NP-complete
During the last years, the genomes of more and more species have been sequenced, providing data for phylogenetic reconstruction based on genome rearrangement measures, where the m...
Martin Bader