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» A parameter-less genetic algorithm
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BMCBI
2010
131views more  BMCBI 2010»
13 years 10 months ago
JISTIC: Identification of Significant Targets in Cancer
Background: Cancer is caused through a multistep process, in which a succession of genetic changes, each conferring a competitive advantage for growth and proliferation, leads to ...
Felix Sanchez-Garcia, Uri David Akavia, Eyal Mozes...
BMCBI
2008
219views more  BMCBI 2008»
13 years 10 months ago
Classification of premalignant pancreatic cancer mass-spectrometry data using decision tree ensembles
Background: Pancreatic cancer is the fourth leading cause of cancer death in the United States. Consequently, identification of clinically relevant biomarkers for the early detect...
Guangtao Ge, G. William Wong
BMCBI
2008
99views more  BMCBI 2008»
13 years 10 months ago
Exhaustive prediction of disease susceptibility to coding base changes in the human genome
Background: Single Nucleotide Polymorphisms (SNPs) are the most abundant form of genomic variation and can cause phenotypic differences between individuals, including diseases. Ba...
Vinayak Kulkarni, Mounir Errami, Robert Barber, Ha...
BMCBI
2007
110views more  BMCBI 2007»
13 years 9 months ago
Selection of long oligonucleotides for gene expression microarrays using weighted rank-sum strategy
Background: The design of long oligonucleotides for spotted DNA microarrays requires detailed attention to ensure their optimal performance in the hybridization process. The main ...
Guangan Hu, Manuel Llinás, Jingguang Li, Pe...
MST
2006
149views more  MST 2006»
13 years 9 months ago
Parameterized Intractability of Distinguishing Substring Selection
A central question in computational biology is the design of genetic markers to distinguish between two given sets of (DNA) sequences. This question is formalized as the NP-comple...
Jens Gramm, Jiong Guo, Rolf Niedermeier