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» A polyhedral approach to RNA sequence structure alignment
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CORR
2006
Springer
121views Education» more  CORR 2006»
13 years 8 months ago
Number sequence representation of protein structures based on the second derivative of a folded tetrahedron sequence
A protein is a sequence of amino-acids of length typically less than 1, 000, where there are 20 kinds of amino-acids. In nature, each protein is folded into a well-defined three-d...
Naoto Morikawa
GECCO
2004
Springer
137views Optimization» more  GECCO 2004»
14 years 2 months ago
Evolving Better Multiple Sequence Alignments
Aligning multiple DNA or protein sequences is a fundamental step in the analyses of phylogeny, homology and molecular structure. Heuristic algorithms are applied because optimal mu...
Luke Sheneman, James A. Foster
ACL
2009
13 years 6 months ago
Coordinate Structure Analysis with Global Structural Constraints and Alignment-Based Local Features
We propose a hybrid approach to coordinate structure analysis that combines a simple grammar to ensure consistent global structure of coordinations in a sentence, and features bas...
Kazuo Hara, Masashi Shimbo, Hideharu Okuma, Yuji M...
GCB
2010
Springer
198views Biometrics» more  GCB 2010»
13 years 6 months ago
RNALfoldz: Efficient Prediction of Thermodynamically Stable, Local Secondary Structures
Abstract: The search for local RNA secondary structures and the annotation of unusually stable folding regions in genomic sequences are two well motivated bioinformatic problems. I...
Andreas R. Gruber, Stephan H. F. Bernhart, You Zho...
BMCBI
2010
176views more  BMCBI 2010»
13 years 8 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...