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BMCBI
2007
172views more  BMCBI 2007»
13 years 8 months ago
Bayesian approaches to reverse engineer cellular systems: a simulation study on nonlinear Gaussian networks
Background: Reverse engineering cellular networks is currently one of the most challenging problems in systems biology. Dynamic Bayesian networks (DBNs) seem to be particularly su...
Fulvia Ferrazzi, Paola Sebastiani, Marco Ramoni, R...
SAC
2006
ACM
14 years 2 months ago
Mining and analyzing the topological structure of protein-protein interaction networks
We report a comprehensive evaluation of the topological structure of protein-protein interaction (PPI) networks by mining and analyzing graphs constructed from the publicly availa...
Daniel Duanqing Wu, Xiaohua Hu
BIOINFORMATICS
2008
172views more  BIOINFORMATICS 2008»
13 years 9 months ago
Fitting a geometric graph to a protein-protein interaction network
Motivation: Finding a good network null model for protein-protein interaction (PPI) networks is a fundamental issue. Such a model would provide insights into the interplay between...
Desmond J. Higham, Marija Rasajski, Natasa Przulj
BMCBI
2008
106views more  BMCBI 2008»
13 years 9 months ago
Identification of hot-spot residues in protein-protein interactions by computational docking
Background: The study of protein-protein interactions is becoming increasingly important for biotechnological and therapeutic reasons. We can define two major areas therein: the s...
Solène Grosdidier, Juan Fernández-Re...
VLDB
2002
ACM
83views Database» more  VLDB 2002»
13 years 8 months ago
Searching on the Secondary Structure of Protein Sequences
In spite of the many decades of progress in database research, surprisingly scientists in the life sciences community still struggle with inefficient and awkward tools for queryin...
Laurie Hammel, Jignesh M. Patel