20 search results - page 3 / 4 » A stepwise framework for the normalization of array CGH data |
BMCBI
2010
13 years 7 months ago
2010
Background: DNA copy number aberration (CNA) is very important in the pathogenesis of tumors and other diseases. For example, CNAs may result in suppression of anti-oncogenes and ...
BMCBI
2010
13 years 7 months ago
2010
Background: Genome-wide association studies (GWAS) using Copy Number Variation (CNV) are becoming a central focus of genetic research. CNVs have successfully provided target genom...
BIOINFORMATICS
2006
13 years 7 months ago
2006
Motivation: The need for normalization in microarray experiments has been well documented in the literature. Currently, most analysis methods treat normalization and analysis as a...
BMCBI
2007
13 years 7 months ago
2007
Background: In order to recapitulate tumor progression pathways using epigenetic data, we developed novel clustering and pathway reconstruction algorithms, collectively referred t...
BMCBI
2010
13 years 7 months ago
2010
Background: Both somatic copy number alterations (CNAs) and germline copy number variants (CNVs) that are prevalent in healthy individuals can appear as recurrent changes in compa...