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» Agent-based protein structure prediction
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BMCBI
2007
142views more  BMCBI 2007»
15 years 4 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
BMCBI
2005
162views more  BMCBI 2005»
15 years 4 months ago
Accelerated probabilistic inference of RNA structure evolution
Background: Pairwise stochastic context-free grammars (Pair SCFGs) are powerful tools for evolutionary analysis of RNA, including simultaneous RNA sequence alignment and secondary...
Ian Holmes
BMCBI
2007
94views more  BMCBI 2007»
15 years 4 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...
BMCBI
2008
118views more  BMCBI 2008»
15 years 4 months ago
Inferring transcriptional compensation interactions in yeast via stepwise structure equation modeling
Background: With the abundant information produced by microarray technology, various approaches have been proposed to infer transcriptional regulatory networks. However, few appro...
Grace S. Shieh, Chung-Ming Chen, Ching-Yun Yu, Jui...
EVOW
2004
Springer
15 years 9 months ago
Two-Step Genetic Programming for Optimization of RNA Common-Structure
We present an algorithm for identifying putative non-coding RNA (ncRNA) using an RCSG (RNA Common-Structural Grammar) and show the effectiveness of the algorithm. The algorithm con...
Jin-Wu Nam, Je-Gun Joung, Y. S. Ahn, Byoung-Tak Zh...