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» Aligning alignments exactly
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BMCBI
2007
117views more  BMCBI 2007»
13 years 11 months ago
Supervised multivariate analysis of sequence groups to identify specificity determining residues
Background: Proteins that evolve from a common ancestor can change functionality over time, and it is important to be able identify residues that cause this change. In this paper ...
Iain M. Wallace, Desmond G. Higgins
BMCBI
2006
104views more  BMCBI 2006»
13 years 11 months ago
SinicView: A visualization environment for comparisons of multiple nucleotide sequence alignment tools
Background: Deluged by the rate and complexity of completed genomic sequences, the need to align longer sequences becomes more urgent, and many more tools have thus been developed...
Arthur Chun-Chieh Shih, D. T. Lee, Laurent Lin, Ch...
BIBE
2007
IEEE
128views Bioinformatics» more  BIBE 2007»
14 years 5 months ago
QOMA2: Optimizing the alignment of many sequences
Abstract—We consider the problem of aligning multiple protein sequences with the goal of maximizing the SP (Sum-of-Pairs) score, when the number of sequences is large. The QOMA (...
Xu Zhang, Tamer Kahveci
ALMOB
2008
82views more  ALMOB 2008»
13 years 11 months ago
Protein sequence and structure alignments within one framework
Background: Protein structure alignments are usually based on very different techniques to sequence alignments. We propose a method which treats sequence, structure and even combi...
Gundolf Schenk, Thomas Margraf, Andrew E. Torda
BMCBI
2010
154views more  BMCBI 2010»
13 years 11 months ago
Fine-tuning structural RNA alignments in the twilight zone
Background: A widely used method to find conserved secondary structure in RNA is to first construct a multiple sequence alignment, and then fold the alignment, optimizing a score ...
Andreas Bremges, Stefanie Schirmer, Robert Giegeri...