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BMCBI
2008
78views more  BMCBI 2008»
13 years 11 months ago
A new protein linear motif benchmark for multiple sequence alignment software
Background: Linear motifs (LMs) are abundant short regulatory sites used for modulating the functions of many eukaryotic proteins. They play important roles in post-translational ...
Emmanuel Perrodou, Claudia Chica, Olivier Poch, To...
BMCBI
2007
142views more  BMCBI 2007»
13 years 11 months ago
Improving model construction of profile HMMs for remote homology detection through structural alignment
Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Juliana S. Bernardes, Alberto M. R. Dávila,...
DM
2010
97views more  DM 2010»
13 years 11 months ago
Random preorders and alignments
A preorder consists of linearly ordered equivalence classes called blocks, and an alignment is a sequence of cycles on n labelled elements. We investigate the block structure of a...
Peter J. Cameron, Mihyun Kang, Dudley Stark
BMCBI
2006
129views more  BMCBI 2006»
13 years 11 months ago
Improved alignment quality by combining evolutionary information, predicted secondary structure and self-organizing maps
Background: Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic t...
Tomas Ohlson, Varun Aggarwal, Arne Elofsson, Rober...
TCBB
2008
95views more  TCBB 2008»
13 years 11 months ago
Solving the Problem of Trans-Genomic Query with Alignment Tables
Abstract-- The trans-genomic query (TGQ) problem -- enabling the free query of biological information, even across genomes -- is a central challenge facing bioinformatics. Solution...
Douglas Stott Parker Jr., Ruey-Lung Hsiao, Yi Xing...