For as long as biologists have been computing alignments of sequences, the question of what values to use for scoring substitutions and gaps has persisted. While some choices for s...
Background: Currently available methods to predict splice sites are mainly based on the independent and progressive alignment of transcript data (mostly ESTs) to the genomic seque...
Background: Existing sequence alignment algorithms assume that similarities between DNA or amino acid sequences are linearly ordered. That is, stretches of similar nucleotides or ...
—DNA matching is a crucial step in sequence alignment. Since sequence alignment is an approximate matching process there is a need for good approximate algorithms. The process of...
Sara Nasser, Gregory Vert, Monica N. Nicolescu, Al...
Abstract. There are several computer programs that align mRNA with its genomic counterpart to determine exon boundaries. Though most of these programs perform such alignment effici...