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» An Auxiliary Variational Method
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132
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ALMOB
2008
85views more  ALMOB 2008»
15 years 3 months ago
Noisy: Identification of problematic columns in multiple sequence alignments
Motivation: Sequence-based methods for phylogenetic reconstruction from (nucleic acid) sequence data are notoriously plagued by two effects: homoplasies and alignment errors. Larg...
Andreas W. M. Dress, Christoph Flamm, Guido Fritzs...
162
Voted
BMCBI
2010
153views more  BMCBI 2010»
15 years 3 months ago
Metamotifs - a generative model for building families of nucleotide position weight matrices
Background: Development of high-throughput methods for measuring DNA interactions of transcription factors together with computational advances in short motif inference algorithms...
Matias Piipari, Thomas A. Down, Tim J. P. Hubbard
BMCBI
2010
89views more  BMCBI 2010»
15 years 3 months ago
Leukocyte Nucleus Segmentation and Nucleus Lobe Counting
Background: Leukocytes play an important role in the human immune system. The family of leukocytes is comprised of lymphocytes, monocytes, eosinophils, basophils, and neutrophils....
Yung-Kuan Chan, Meng-Hsiun Tsai, Der-Chen Huang, Z...
120
Voted
BMCBI
2007
145views more  BMCBI 2007»
15 years 3 months ago
Genome bioinformatic analysis of nonsynonymous SNPs
Background: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the mos...
David F. Burke, Catherine L. Worth, Eva-Maria Prie...
129
Voted
BMCBI
2008
149views more  BMCBI 2008»
15 years 3 months ago
Clustering of cognate proteins among distinct proteomes derived from multiple links to a single seed sequence
Background: Modern proteomes evolved by modification of pre-existing ones. It is extremely important to comparative biology that related proteins be identified as members of the s...
Adriano Barbosa-Silva, Venkata P. Satagopam, Reinh...