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BMCBI
2010
154views more  BMCBI 2010»
13 years 5 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...
BMCBI
2007
78views more  BMCBI 2007»
13 years 7 months ago
Improved human disease candidate gene prioritization using mouse phenotype
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
Jing Chen, Huan Xu, Bruce J. Aronow, Anil G. Jegga
BMCBI
2010
124views more  BMCBI 2010»
13 years 7 months ago
A factor model to analyze heterogeneity in gene expression
Background: Microarray technology allows the simultaneous analysis of thousands of genes within a single experiment. Significance analyses of transcriptomic data ignore the gene d...
Yuna Blum, Guillaume Le Mignon, Sandrine Lagarrigu...
BMCBI
2007
135views more  BMCBI 2007»
13 years 7 months ago
Measuring similarities between gene expression profiles through new data transformations
Background: Clustering methods are widely used on gene expression data to categorize genes with similar expression profiles. Finding an appropriate (dis)similarity measure is crit...
Kyungpil Kim, Shibo Zhang, Keni Jiang, Li Cai, In-...
CMSB
2006
Springer
13 years 11 months ago
Possibilistic Approach to Biclustering: An Application to Oligonucleotide Microarray Data Analysis
Abstract. The important research objective of identifying genes with similar behavior with respect to different conditions has recently been tackled with biclustering techniques. I...
Maurizio Filippone, Francesco Masulli, Stefano Rov...