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» An Implementation Model for Collaborative Applications
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129
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BMCBI
2010
154views more  BMCBI 2010»
15 years 2 months ago
Motif Enrichment Analysis: a unified framework and an evaluation on ChIP data
Background: A major goal of molecular biology is determining the mechanisms that control the transcription of genes. Motif Enrichment Analysis (MEA) seeks to determine which DNA-b...
Robert C. McLeay, Timothy L. Bailey
120
Voted
BMCBI
2010
113views more  BMCBI 2010»
15 years 2 months ago
Unifying generative and discriminative learning principles
Background: The recognition of functional binding sites in genomic DNA remains one of the fundamental challenges of genome research. During the last decades, a plethora of differe...
Jens Keilwagen, Jan Grau, Stefan Posch, Marc Stric...
124
Voted
BMCBI
2008
106views more  BMCBI 2008»
15 years 2 months ago
Ontology Design Patterns for bio-ontologies: a case study on the Cell Cycle Ontology
Background: Bio-ontologies are key elements of knowledge management in bioinformatics. Rich and rigorous bio-ontologies should represent biological knowledge with high fidelity an...
Mikel Egaña Aranguren, Erick Antezana, Mart...
119
Voted
BMCBI
2006
100views more  BMCBI 2006»
15 years 2 months ago
Empirical array quality weights in the analysis of microarray data
Background: Assessment of array quality is an essential step in the analysis of data from microarray experiments. Once detected, less reliable arrays are typically excluded or &qu...
Matthew E. Ritchie, Dileepa S. Diyagama, Jody Neil...
ENVSOFT
2006
72views more  ENVSOFT 2006»
15 years 2 months ago
Integrating legacy components into a software system for storm sewer simulation
This paper presents an approach that integrates a legacy component into a software system for storm sewer simulation. The legacy component employed here is the Storm Water Managem...
Shiu-Shin Lin, Shang-Hsien Hsieh, Jan-Tai Kuo, Yin...