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BMCBI
2010
152views more  BMCBI 2010»
13 years 8 months ago
A high-throughput de novo sequencing approach for shotgun proteomics using high-resolution tandem mass spectrometry
Background: High-resolution tandem mass spectra can now be readily acquired with hybrid instruments, such as LTQ-Orbitrap and LTQ-FT, in high-throughput shotgun proteomics workflo...
Chongle Pan, Byung-Hoon Park, William H. McDonald,...
BMCBI
2006
166views more  BMCBI 2006»
13 years 8 months ago
SEQOPTICS: a protein sequence clustering system
Background: Protein sequence clustering has been widely used as a part of the analysis of protein structure and function. In most cases single linkage or graph-based clustering al...
Yonghui Chen, Kevin D. Reilly, Alan P. Sprague, Zh...
BIBM
2008
IEEE
112views Bioinformatics» more  BIBM 2008»
14 years 2 months ago
Predicting Protective Linear B-Cell Epitopes Using Evolutionary Information
Mapping B-cell epitopes plays an important role in vaccine design, immunodiagnostic tests, and antibody production. Because the experimental determination of B-cell epitopes is ti...
Yasser El-Manzalawy, Drena Dobbs, Vasant Honavar
BMCBI
2010
176views more  BMCBI 2010»
13 years 8 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...
BMCBI
2008
123views more  BMCBI 2008»
13 years 8 months ago
Ori-Finder: A web-based system for finding oriCs in unannotated bacterial genomes
Background: Chromosomal replication is the central event in the bacterial cell cycle. Identification of replication origins (oriCs) is necessary for almost all newly sequenced bac...
Feng Gao, Chun-Ting Zhang