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» Analysis of Large-Scale Sequencing of Small RNAs
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JCB
2007
94views more  JCB 2007»
13 years 7 months ago
Locality and Gaps in RNA Comparison
Locality is an important and well-studied notion in comparative analysis of biological sequences. Similarly, taking into account affine gap penalties when calculating biological ...
Rolf Backofen, Shihyen Chen, Danny Hermelin, Gad M...
BMCBI
2010
147views more  BMCBI 2010»
13 years 7 months ago
baySeq: Empirical Bayesian methods for identifying differential expression in sequence count data
Background: High throughput sequencing has become an important technology for studying expression levels in many types of genomic, and particularly transcriptomic, data. One key w...
Thomas J. Hardcastle, Krystyna A. Kelly
BMCBI
2007
94views more  BMCBI 2007»
13 years 7 months ago
Model based analysis of real-time PCR data from DNA binding dye protocols
Background: Reverse transcription followed by real-time PCR is widely used for quantification of specific mRNA, and with the use of double-stranded DNA binding dyes it is becoming...
Mariano J. Alvarez, Guillermo J. Vila-Ortiz, Maria...
BMCBI
2007
94views more  BMCBI 2007»
13 years 7 months ago
A structural analysis of in vitro catalytic activities of hammerhead ribozymes
Background: Ribozymes are small catalytic RNAs that possess the dual functions of sequencespecific RNA recognition and site-specific cleavage. Trans-cleaving ribozymes can inhibit...
Yu Shao, Susan Wu, Chi Yu Chan, Jessie R. Klapper,...
BMCBI
2004
115views more  BMCBI 2004»
13 years 7 months ago
An SVD-based comparison of nine whole eukaryotic genomes supports a coelomate rather than ecdysozoan lineage
Background: Eukaryotic whole genome sequences are accumulating at an impressive rate. Effective methods for comparing multiple whole eukaryotic genomes on a large scale are needed...
Gary W. Stuart, Michael W. Berry