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» Analysis of Metabolic Pathways by Graph Transformation
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BIRD
2008
Springer
158views Bioinformatics» more  BIRD 2008»
13 years 10 months ago
A Computational Method for Reconstructing Gapless Metabolic Networks
Abstract. We propose a computational method for reconstructing metabolic networks. The method utilizes optimization techniques and graph traversal algorithms to discover a set of b...
Esa Pitkänen, Ari Rantanen, Juho Rousu, Esko ...
BMCBI
2004
151views more  BMCBI 2004»
13 years 8 months ago
A computational approach for ordering signal transduction pathway components from genomics and proteomics Data
Background: Signal transduction is one of the most important biological processes by which cells convert an external signal into a response. Novel computational approaches to mapp...
Yin Liu, Hongyu Zhao
BMCBI
2007
93views more  BMCBI 2007»
13 years 8 months ago
The topology of metabolic isotope labeling networks
Background: Metabolic Flux Analysis (MFA) based on isotope labeling experiments (ILEs) is a widely established tool for determining fluxes in metabolic pathways. Isotope labeling ...
Michael Weitzel, Wolfgang Wiechert, Katharina N&ou...
ECAI
2004
Springer
14 years 1 months ago
Towards a Logical Analysis of Biochemical Reactions
We provide a logical model of biochemical reactions and show how hypothesis generation using weakest sufficient and strongest necessary conditions may be used to provide addition...
Patrick Doherty, Steve Kertes, Martin Magnusson, A...
BMCBI
2010
154views more  BMCBI 2010»
13 years 6 months ago
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation
Background: External stimulations of cells by hormones, cytokines or growth factors activate signal transduction pathways that subsequently induce a re-arrangement of cellular gen...
Andreas Kowarsch, Florian Blöchl, Sebastian B...