Background: Protein-protein association is essential for a variety of cellular processes and hence a large number of investigations are being carried out to understand the princip...
Background: Biological evolution conserves protein residues that are important for structure and function. Both protein stability and function often require a certain degree of st...
Background: Many newly detected point mutations are located in protein-coding regions of the human genome. Knowledge of their effects on the protein's 3D structure provides i...
Hanka Venselaar, Tim A. H. te Beek, Remko K. P. Ku...
Background: The identification of local similarities between two protein structures can provide clues of a common function. Many different methods exist for searching for similar ...
Background: Many dimeric protein complexes bind cooperatively to families of bipartite nucleic acid sequence elements, which consist of pairs of conserved half-site sequences sepa...