Oligomeric protein structure networks: insights into protein-protein interactions

Background: Protein-protein association is essential for a variety of cellular processes and hence a large number of investigations are being carried out to understand the principles of proteinprotein interactions. In this study, oligomeric protein structures are viewed from a network perspective to obtain new insights into protein association. Structure graphs of proteins have been constructed from a non-redundant set of protein oligomer crystal structures by considering amino acid residues as nodes and the edges are based on the strength of the non-covalent interactions between the residues. The analysis of such networks has been carried out in terms of amino acid clusters and hubs (highly connected residues) with special emphasis to protein interfaces. Results: A variety of interactions such as hydrogen bond, salt bridges, aromatic and hydrophobic interactions, which occur at the interfaces are identified in a consolidated manner as amino acid clusters at the interface, from this s...

• Type: Journal
• Year: 2005
• Where: BMCBI
• Authors: K. V. Brinda, Saraswathi Vishveshwara
• Keywords: Acid Clusters, Amino Acid, BMCBI 2005, Protein