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BMCBI
2008
159views more  BMCBI 2008»
13 years 11 months ago
Estimation and testing for the effect of a genetic pathway on a disease outcome using logistic kernel machine regression via log
Background: Growing interest on biological pathways has called for new statistical methods for modeling and testing a genetic pathway effect on a health outcome. The fact that gen...
Dawei Liu, Debashis Ghosh, Xihong Lin
BMCBI
2008
160views more  BMCBI 2008»
13 years 11 months ago
Predicting cancer involvement of genes from heterogeneous data
Background: Systematic approaches for identifying proteins involved in different types of cancer are needed. Experimental techniques such as microarrays are being used to characte...
Ramon Aragues, Chris Sander, Baldo Oliva
BMCBI
2008
98views more  BMCBI 2008»
13 years 11 months ago
Normalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
Background: Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aber...
Johan Staaf, Johan Vallon-Christersson, David Lind...
BMCBI
2008
106views more  BMCBI 2008»
13 years 11 months ago
Ontology Design Patterns for bio-ontologies: a case study on the Cell Cycle Ontology
Background: Bio-ontologies are key elements of knowledge management in bioinformatics. Rich and rigorous bio-ontologies should represent biological knowledge with high fidelity an...
Mikel Egaña Aranguren, Erick Antezana, Mart...
CONCURRENCY
2010
130views more  CONCURRENCY 2010»
13 years 11 months ago
Enabling high-speed asynchronous data extraction and transfer using DART
As the complexity and scale of current scientific and engineering applications grow, managing and transporting the large amounts of data they generate is quickly becoming a signif...
Ciprian Docan, Manish Parashar, Scott Klasky
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