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» Analyzing Pathways Using SAT-Based Approaches
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BMCBI
2010
110views more  BMCBI 2010»
13 years 10 months ago
Towards the systematic discovery of signal transduction networks using phosphorylation dynamics data
Background: Phosphorylation is a ubiquitous and fundamental regulatory mechanism that controls signal transduction in living cells. The number of identified phosphoproteins and th...
Haruna Imamura, Nozomu Yachie, Rintaro Saito, Yasu...
BMCBI
2011
13 years 1 months ago
Fusion of metabolomics and proteomics data for biomarkers discovery: case study on the experimental autoimmune encephalomyelitis
Background: Analysis of Cerebrospinal Fluid (CSF) samples holds great promise to diagnose neurological pathologies and gain insight into the molecular background of these patholog...
Lionel Blanchet, Agnieszka Smolinska, Amos Attali,...
BMCBI
2006
85views more  BMCBI 2006»
13 years 9 months ago
Use of physiological constraints to identify quantitative design principles for gene expression in yeast adaptation to heat shoc
Background: Understanding the relationship between gene expression changes, enzyme activity shifts, and the corresponding physiological adaptive response of organisms to environme...
Ester Vilaprinyó, Rui Alves, Albert Sorriba...
BMCBI
2007
129views more  BMCBI 2007»
13 years 10 months ago
Integrated network reconstruction, visualization and analysis using YANAsquare
Background: Modeling of metabolic networks includes tasks such as network assembly, network overview, calculation of metabolic fluxes and testing the robustness of the network. Re...
Roland Schwarz, Chunguang Liang, Christoph Kaleta,...
JMLR
2010
105views more  JMLR 2010»
13 years 4 months ago
Evaluation of Signaling Cascades Based on the Weights from Microarray and ChIP-seq Data
In this study, we combined the ChIP-seq and the transcriptome data and integrated these data into signaling cascades. Integration was realized through a framework based on data- a...
Zerrin Isik, Volkan Atalay, Rengül Çet...