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» Application of Evolutionary Algorithms to Protein Folding Pr...
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BMCBI
2008
128views more  BMCBI 2008»
13 years 8 months ago
Pairwise covariance adds little to secondary structure prediction but improves the prediction of non-canonical local structure
Background: Amino acid sequence probability distributions, or profiles, have been used successfully to predict secondary structure and local structure in proteins. Profile models ...
Christopher Bystroff, Bobbie-Jo M. Webb-Robertson
CEC
2009
IEEE
14 years 2 months ago
Evolutionary design of the energy function for protein structure prediction
— Automatic protein structure predictors use the notion of energy to guide the search towards good candidate structures. The energy functions used by the state-of-the-art predict...
Pawel Widera, Jonathan M. Garibaldi, Natalio Krasn...
BMCBI
2008
101views more  BMCBI 2008»
13 years 8 months ago
Prediction of glycosylation sites using random forests
Background: Post translational modifications (PTMs) occur in the vast majority of proteins and are essential for function. Prediction of the sequence location of PTMs enhances the...
Stephen E. Hamby, Jonathan D. Hirst
BMCBI
2010
108views more  BMCBI 2010»
13 years 8 months ago
Predicting changes in protein thermostability brought about by single- or multi-site mutations
Background: An important aspect of protein design is the ability to predict changes in protein thermostability arising from single- or multi-site mutations. Protein thermostabilit...
Jian Tian, Ningfeng Wu, Xiaoyu Chu, Yunliu Fan
BMCBI
2007
128views more  BMCBI 2007»
13 years 8 months ago
A robust and efficient algorithm for the shape description of protein structures and its application in predicting ligand bindin
Background: An accurate description of protein shape derived from protein structure is necessary to establish an understanding of protein-ligand interactions, which in turn will l...
Lei Xie, Philip E. Bourne