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BMCBI
2010
154views more  BMCBI 2010»
13 years 8 months ago
Binary image representation of a ligand binding site: its application to efficient sampling of a conformational ensemble
Background: Modelling the ligand binding site of a protein is an important component of understanding proteinligand interactions and is being actively studied. Even if the side ch...
Edon Sung, Sangsoo Kim, Whanchul Shin
BMCBI
2004
125views more  BMCBI 2004»
13 years 7 months ago
A fast algorithm for determining the best combination of local alignments to a query sequence
Background: Existing sequence alignment algorithms assume that similarities between DNA or amino acid sequences are linearly ordered. That is, stretches of similar nucleotides or ...
Gavin C. Conant, Andreas Wagner
RECOMB
2006
Springer
14 years 8 months ago
Assessing Significance of Connectivity and Conservation in Protein Interaction Networks
Computational and comparative analysis of protein-protein interaction (PPI) networks enable understanding of the modular organization of the cell through identification of functio...
Mehmet Koyutürk, Ananth Grama, Wojciech Szpan...
RECOMB
2008
Springer
14 years 8 months ago
Fast and Accurate Alignment of Multiple Protein Networks
Comparative analysis of protein networks has proven to be a powerful approach for elucidating network structure and predicting protein function and interaction. A fundamental chall...
Maxim Kalaev, Vineet Bafna, Roded Sharan
BMCBI
2010
176views more  BMCBI 2010»
13 years 8 months ago
TargetSpy: a supervised machine learning approach for microRNA target prediction
Background: Virtually all currently available microRNA target site prediction algorithms require the presence of a (conserved) seed match to the 5' end of the microRNA. Recen...
Martin Sturm, Michael Hackenberg, David Langenberg...