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104
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BMCBI
2010
105views more  BMCBI 2010»
15 years 3 months ago
A knowledge-guided strategy for improving the accuracy of scoring functions in binding affinity prediction
Background: Current scoring functions are not very successful in protein-ligand binding affinity prediction albeit their popularity in structure-based drug designs. Here, we propo...
Tiejun Cheng, Zhihai Liu, Renxiao Wang
128
Voted
BMCBI
2007
95views more  BMCBI 2007»
15 years 3 months ago
ZPS: visualization of recent adaptive evolution of proteins
Background: Detection of adaptive amino acid changes in proteins under recent short-term selection is of great interest for researchers studying microevolutionary processes in mic...
Sujay Chattopadhyay, Daniel E. Dykhuizen, Evgeni V...
136
Voted
BMCBI
2010
149views more  BMCBI 2010»
15 years 3 months ago
RuleMonkey: software for stochastic simulation of rule-based models
Background: The system-level dynamics of many molecular interactions, particularly protein-protein interactions, can be conveniently represented using reaction rules, which can be...
Joshua Colvin, Michael I. Monine, Ryan N. Gutenkun...
131
Voted
BMCBI
2008
110views more  BMCBI 2008»
15 years 3 months ago
Testing for treatment effects on gene ontology
In studies that use DNA arrays to assess changes in gene expression, it is preferable to measure the significance of treatment effects on a group of genes from a pathway or functi...
Taewon Lee, Varsha G. Desai, Cruz Velasco, Robert ...
148
Voted
BMCBI
2007
187views more  BMCBI 2007»
15 years 3 months ago
BioWMS: a web-based Workflow Management System for bioinformatics
Background: An in-silico experiment can be naturally specified as a workflow of activities implementing, in a standardized environment, the process of data and control analysis. A...
Ezio Bartocci, Flavio Corradini, Emanuela Merelli,...
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