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BMCBI
2006
100views more  BMCBI 2006»
15 years 4 months ago
Using the nucleotide substitution rate matrix to detect horizontal gene transfer
Background: Horizontal gene transfer (HGT) has allowed bacteria to evolve many new capabilities. Because transferred genes perform many medically important functions, such as conf...
Micah Hamady, M. D. Betterton, Rob Knight
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BMCBI
2006
130views more  BMCBI 2006»
15 years 4 months ago
4SALE - A tool for synchronous RNA sequence and secondary structure alignment and editing
Background: In sequence analysis the multiple alignment builds the fundament of all proceeding analyses. Errors in an alignment could strongly influence all succeeding analyses an...
Philipp N. Seibel, Tobias Müller, Thomas Dand...
BMCBI
2006
94views more  BMCBI 2006»
15 years 4 months ago
Noise-injected neural networks show promise for use on small-sample expression data
Background: Overfitting the data is a salient issue for classifier design in small-sample settings. This is why selecting a classifier from a constrained family of classifiers, on...
Jianping Hua, James Lowey, Zixiang Xiong, Edward R...
BMCBI
2007
104views more  BMCBI 2007»
15 years 4 months ago
A response to Yu et al. "A forward-backward fragment assembling algorithm for the identification of genomic amplification and de
Background: Yu et al. (BMC Bioinformatics 2007,8: 145+) have recently compared the performance of several methods for the detection of genomic amplification and deletion breakpoin...
Oscar M. Rueda, Ramón Díaz-Uriarte
BMCBI
2007
123views more  BMCBI 2007»
15 years 4 months ago
BIRCH: A user-oriented, locally-customizable, bioinformatics system
Background: Molecular biologists need sophisticated analytical tools which often demand extensive computational resources. While finding, installing, and using these tools can be ...
Brian Fristensky