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JCB
2008
159views more  JCB 2008»
13 years 7 months ago
BayesMD: Flexible Biological Modeling for Motif Discovery
We present BayesMD, a Bayesian Motif Discovery model with several new features. Three different types of biological a priori knowledge are built into the framework in a modular fa...
Man-Hung Eric Tang, Anders Krogh, Ole Winther
BMCBI
2004
150views more  BMCBI 2004»
13 years 7 months ago
Cross-species comparison significantly improves genome-wide prediction of cis-regulatory modules in Drosophila
Background: The discovery of cis-regulatory modules in metazoan genomes is crucial for understanding the connection between genes and organism diversity. It is important to quanti...
Saurabh Sinha, Mark D. Schroeder, Ulrich Unnerstal...
BIOCOMP
2006
13 years 8 months ago
Computational Inference of Compound-induced Anti-inflammatory Effects Across Time in an Adjuvant-induced Arthritis Rat Model
A number of diseases, such as arthritis and cardiovascular disorders impacting the lives of many people have strong inflammatory components. To elucidate the antiinflammatory mecha...
Jing Yu, Gabriel Helmlinger, Muriel Saulnier, Anna...
BMCBI
2007
141views more  BMCBI 2007»
13 years 7 months ago
HeliCis: a DNA motif discovery tool for colocalized motif pairs with periodic spacing
Background: Correct temporal and spatial gene expression during metazoan development relies on combinatorial interactions between different transcription factors. As a consequence...
Erik Larsson, Per Lindahl, Petter Mostad