Background: RNA metabolism, through 'combinatorial splicing', can generate enormous structural diversity in the proteome. Alternative domains may interact, however, with...
Mark C. Emerick, Giovanni Parmigiani, William S. A...
Based on speculations coming from statistical mechanics and the conjectured existence of critical states, I propose a simple heuristic in order to control the mutation probability...
Background: In binary high-throughput screening projects where the goal is the identification of low-frequency events, beyond the obvious issue of efficiency, false positives and ...
Scatter search is an evolutionary method that has been successfully applied to hard optimization problems. The fundamental concepts and principles of the method were first propose...
Background: Support Vector Machines (SVMs) provide a powerful method for classification (supervised learning). Use of SVMs for clustering (unsupervised learning) is now being cons...