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BMCBI
2011
13 years 2 months ago
Systematic error detection in experimental high-throughput screening
Background: High-throughput screening (HTS) is a key part of the drug discovery process during which thousands of chemical compounds are screened and their activity levels measure...
Plamen Dragiev, Robert Nadon, Vladimir Makarenkov
AUTOMATICA
2008
123views more  AUTOMATICA 2008»
13 years 7 months ago
Identification with stochastic sampling time jitter
This work investigates how stochastic sampling jitter noise affects the result of system identification, and proposes a modification of known approaches to mitigate the effects of...
Frida Eng, Fredrik Gustafsson
BMCBI
2006
175views more  BMCBI 2006»
13 years 7 months ago
Parameter estimation for stiff equations of biosystems using radial basis function networks
Background: The modeling of dynamic systems requires estimating kinetic parameters from experimentally measured time-courses. Conventional global optimization methods used for par...
Yoshiya Matsubara, Shinichi Kikuchi, Masahiro Sugi...
ICCD
2007
IEEE
157views Hardware» more  ICCD 2007»
14 years 4 months ago
Combining cluster sampling with single pass methods for efficient sampling regimen design
Microarchitectural simulation is orders of magnitude slower than native execution. As more elements are accurately modeled, problems associated with slow simulation are further ex...
Paul D. Bryan, Thomas M. Conte
NECO
2002
100views more  NECO 2002»
13 years 7 months ago
Robust Regression with Asymmetric Heavy-Tail Noise Distributions
In the presence of a heavy-tail noise distribution, regression becomes much more di cult. Traditional robust regression methods assume that the noise distribution is symmetric and...
Ichiro Takeuchi, Yoshua Bengio, Takafumi Kanamori