Motivation: Existing methods for protein sequence analysis are generally firstorder and inherently assume that each position is independent. We develop a general framework for int...
Martin Madera, Ryan Calmus, Grant Thiltgen, Kevin ...
Background: Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic t...
Tomas Ohlson, Varun Aggarwal, Arne Elofsson, Rober...
- Though prediction of protein secondary structures has been an active research issue in bioinformatics for quite a few years and many approaches have been proposed, a new challeng...
Accurately aligning distant protein sequences is notoriously difficult. A recent approach to improving alignment accuracy is to use additional information such as predicted seconda...
Predicting the three-dimensional structure of proteins is a hard problem, so many have opted instead to predict the secondary structural state (usually helix, strand or coil) of e...