Background: Remote homology detection is a challenging problem in Bioinformatics. Arguably, profile Hidden Markov Models (pHMMs) are one of the most successful approaches in addre...
Background: Protein sequence alignment is one of the basic tools in bioinformatics. Correct alignments are required for a range of tasks including the derivation of phylogenetic t...
Tomas Ohlson, Varun Aggarwal, Arne Elofsson, Rober...
Background: One of the most powerful methods for the prediction of protein structure from sequence information alone is the iterative construction of profile-type models. Because ...
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, d...
Daniel A. Pollard, Alan M. Moses, Venky N. Iyer, M...
During the last few years new functionalities of RNA have been discovered, renewing the need for computational tools for their analysis. To this respect, multiple sequence alignmen...