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BMCBI
2010
182views more  BMCBI 2010»
13 years 10 months ago
Beyond co-localization: inferring spatial interactions between sub-cellular structures from microscopy images
Background: Sub-cellular structures interact in numerous direct and indirect ways in order to fulfill cellular functions. While direct molecular interactions crucially depend on s...
Jo A. Helmuth, Grégory Paul, Ivo F. Sbalzar...
CBMS
2001
IEEE
14 years 1 months ago
An Interoperable Data Architecture for Data Exchange in a Biomedical Research Network
Knowledge discovery and data correlation require a unified approach to basic data management. However, achieving such an approach is nearly impossible with hundreds of disparate d...
Daniel J. Crichton, J. Steven Hughes, Gregory J. D...
BMCBI
2007
157views more  BMCBI 2007»
13 years 10 months ago
Improving gene set analysis of microarray data by SAM-GS
Background: Gene-set analysis evaluates the expression of biological pathways, or a priori defined gene sets, rather than that of individual genes, in association with a binary ph...
Irina Dinu, John D. Potter, Thomas Mueller, Qi Liu...
BMCBI
2008
179views more  BMCBI 2008»
13 years 10 months ago
Bayesian modeling of recombination events in bacterial populations
Background: We consider the discovery of recombinant segments jointly with their origins within multilocus DNA sequences from bacteria representing heterogeneous populations of fa...
Pekka Marttinen, Adam Baldwin, William P. Hanage, ...
BMCBI
2010
153views more  BMCBI 2010»
13 years 10 months ago
Starr: Simple Tiling ARRay analysis of Affymetrix ChIP-chip data
Background: Chromatin immunoprecipitation combined with DNA microarrays (ChIP-chip) is an assay used for investigating DNA-protein-binding or post-translational chromatin/histone ...
Benedikt Zacher, Pei Fen Kuan, Achim Tresch