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BMCBI
2010
191views more  BMCBI 2010»
13 years 10 months ago
BiGG: a Biochemical Genetic and Genomic knowledgebase of large scale metabolic reconstructions
Background: Genome-scale metabolic reconstructions under the Constraint Based Reconstruction and Analysis (COBRA) framework are valuable tools for analyzing the metabolic capabili...
Jan Schellenberger, Junyoung O. Park, Tom M. Conra...
BMCBI
2007
109views more  BMCBI 2007»
13 years 10 months ago
TABASCO: A single molecule, base-pair resolved gene expression simulator
Background: Experimental studies of gene expression have identified some of the individual molecular components and elementary reactions that comprise and control cellular behavio...
Sriram Kosuri, Jason R. Kelly, Drew Endy
COMPUTER
2008
84views more  COMPUTER 2008»
13 years 10 months ago
e-Science, caGrid, and Translational Biomedical Research
We describe the informatics requirements of translational biomedical research projects and how e-Science tools can be used to address them. We use pattern templates to describe the...
Joel H. Saltz, Tahsin M. Kurç, Shannon Hast...
BMCBI
2006
151views more  BMCBI 2006»
13 years 10 months ago
Modeling Sage data with a truncated gamma-Poisson model
Background: Serial Analysis of Gene Expressions (SAGE) produces gene expression measurements on a discrete scale, due to the finite number of molecules in the sample. This means t...
Helene H. Thygesen, Aeilko H. Zwinderman
BMCBI
2006
108views more  BMCBI 2006»
13 years 10 months ago
Improved Chou-Fasman method for protein secondary structure prediction
Background: Protein secondary structure prediction is a fundamental and important component in the analytical study of protein structure and functions. The prediction technique ha...
Hang Chen, Fei Gu, Zhengge Huang