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» Building Large Knowledge Bases in Molecular Biology
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NAR
2006
87views more  NAR 2006»
13 years 7 months ago
From genomics to chemical genomics: new developments in KEGG
The increasing amount of genomic and molecular information is the basis for understanding higherorder biological systems, such as the cell and the 15 organism, and their interacti...
Minoru Kanehisa, Susumu Goto, Masahiro Hattori, Ki...
ISMB
1996
13 years 8 months ago
A Knowledge-Based Method for Protein Structure Refinement and Prediction
The native conformation of a protein, in a given environment, is determined entirely by the various interatomic interactions dictated by the amino acid sequence (1-3). We describe...
Shankar Subramaniam, David K. Tcheng, James M. Fen...
ISMB
1997
13 years 8 months ago
RIBOWEB: Linking Structural Computations to a Knowledge Base of Published Experimental Data
The world wide web(WWW)has becomecritical for storing and disseminatingbiological data. It offers an additional opportunity, however,to support distributed computation and sharing...
Richard O. Chen, Ramon M. Felciano, Russ B. Altman
RECOMB
2005
Springer
14 years 7 months ago
Comparative Systems Biology of the Sporulation Initiation Network in Prokaryotes
Many years of experimental and computational molecular biology of model organisms such as Escherichia coli and Saccharomyces cerevisiae has elucidated the gene regulatory network i...
Michiel J. L. de Hoon, Dennis Vitkup
ISMB
2007
13 years 9 months ago
A Chado case study: an ontology-based modular schema for representing genome-associated biological information
Motivation: A few years ago, FlyBase undertook to design a new database schema to store Drosophila data. It would fully integrate genomic sequence and annotation data with bibliog...
Chris Mungall, David B. Emmert