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» CONTRAlign: Discriminative Training for Protein Sequence Ali...
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BMCBI
2008
114views more  BMCBI 2008»
13 years 6 months ago
Combining classifiers for improved classification of proteins from sequence or structure
Background: Predicting a protein's structural or functional class from its amino acid sequence or structure is a fundamental problem in computational biology. Recently, there...
Iain Melvin, Jason Weston, Christina S. Leslie, Wi...
BMCBI
2005
100views more  BMCBI 2005»
13 years 6 months ago
Scoredist: A simple and robust protein sequence distance estimator
Background: Distance-based methods are popular for reconstructing evolutionary trees thanks to their speed and generality. A number of methods exist for estimating distances from ...
Erik L. L. Sonnhammer, Volker Hollich
BIOCOMP
2010
13 years 3 months ago
Using the Genetic Code Wisdom for Recognizing Protein Coding Sequences
We have elaborated a new method of recognizing protein coding sequences in genomic sequences. The method is exploiting a specific way of genetic code degeneration and relations bet...
Pawel Blazej, Pawel Mackiewicz, Stanislaw Cebrat
BMCBI
2007
101views more  BMCBI 2007»
13 years 6 months ago
Relationship between insertion/deletion (indel) frequency of proteins and essentiality
Background: In a previous study, we demonstrated that some essential proteins from pathogenic organisms contained sizable insertions/deletions (indels) when aligned to human prote...
Simon K. Chan, Michael Hsing, Fereydoun Hormozdiar...
BMCBI
2007
144views more  BMCBI 2007»
13 years 6 months ago
Motif kernel generated by genetic programming improves remote homology and fold detection
Background: Protein remote homology detection is a central problem in computational biology. Most recent methods train support vector machines to discriminate between related and ...
Tony Håndstad, Arne J. H. Hestnes, Pål...