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» Can we Find Molecular Signatures from Gene Expression Data
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BMCBI
2007
135views more  BMCBI 2007»
13 years 8 months ago
Detecting multivariate differentially expressed genes
Background: Gene expression is governed by complex networks, and differences in expression patterns between distinct biological conditions may therefore be complex and multivariat...
Roland Nilsson, José M. Peña, Johan ...
BIBE
2007
IEEE
121views Bioinformatics» more  BIBE 2007»
14 years 3 months ago
Identifying Genomic Regulators of Set-Wise Co-Expression
The genetical genomics approach has been used to study the genetic basis of variation in gene expression, where putative transcriptional regulators of genes are identified via gene...
Jung Hoon Woo, Tian Zheng, Ju Han Kim
BMCBI
2006
169views more  BMCBI 2006»
13 years 8 months ago
Beyond microarrays: Finding key transcription factors controlling signal transduction pathways
Background: Massive gene expression changes in different cellular states measured by microarrays, in fact, reflect just an "echo" of real molecular processes in the cell...
Alexander E. Kel, Nico Voss, Ruy Jauregui, Olga V....
BMCBI
2010
97views more  BMCBI 2010»
13 years 8 months ago
Biomarker discovery in heterogeneous tissue samples -taking the in-silico deconfounding approach
Background: For heterogeneous tissues, such as blood, measurements of gene expression are confounded by relative proportions of cell types involved. Conclusions have to rely on es...
Dirk Repsilber, Sabine Kern, Anna Telaar, Gerhard ...
BMCBI
2005
103views more  BMCBI 2005»
13 years 8 months ago
Many accurate small-discriminatory feature subsets exist in microarray transcript data: biomarker discovery
Background: Molecular profiling generates abundance measurements for thousands of gene transcripts in biological samples such as normal and tumor tissues (data points). Given such...
Leslie Grate