The problem of assessing the reliability of clusters patients identified by clustering algorithms is crucial to estimate the significance of subclasses of diseases detectable at b...
Background: A major goal of cancer research is to identify discrete biomarkers that specifically characterize a given malignancy. These markers are useful in diagnosis, may identi...
Virginie M. Aris, Michael J. Cody, Jeff Cheng, Jam...
Background: Recent analyses have suggested that many genes possess multiple transcription start sites (TSSs) that are differentially utilized in different tissues and cell lines. ...
Background: It has been long well known that genes do not act alone; rather groups of genes act in consort during a biological process. Consequently, the expression levels of gene...
Different algorithms have been proposed in the literature to cluster gene expression data, however there is no single algorithm that can be considered the best one independently on...