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» Challenges and prospects in the analysis of large-scale gene...
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BMCBI
2007
123views more  BMCBI 2007»
13 years 6 months ago
Robust clustering in high dimensional data using statistical depths
Background: Mean-based clustering algorithms such as bisecting k-means generally lack robustness. Although componentwise median is a more robust alternative, it can be a poor cent...
Yuanyuan Ding, Xin Dang, Hanxiang Peng, Dawn Wilki...
BMCBI
2007
78views more  BMCBI 2007»
13 years 6 months ago
Improved human disease candidate gene prioritization using mouse phenotype
Background: The majority of common diseases are multi-factorial and modified by genetically and mechanistically complex polygenic interactions and environmental factors. High-thro...
Jing Chen, Huan Xu, Bruce J. Aronow, Anil G. Jegga
KDD
2001
ACM
169views Data Mining» more  KDD 2001»
14 years 7 months ago
Hierarchical cluster analysis of SAGE data for cancer profiling
In this paper we present a method for clustering SAGE (Serial Analysis of Gene Expression) data to detect similarities and dissimilarities between different types of cancer on the...
Jörg Sander, Monica C. Sleumer, Raymond T. Ng
BMCBI
2010
178views more  BMCBI 2010»
13 years 6 months ago
Selecting high-dimensional mixed graphical models using minimal AIC or BIC forests
Background: Chow and Liu showed that the maximum likelihood tree for multivariate discrete distributions may be found using a maximum weight spanning tree algorithm, for example K...
David Edwards, Gabriel C. G. de Abreu, Rodrigo Lab...
CCE
2005
13 years 6 months ago
Selecting maximally informative genes
Microarray experiments are emerging as one of the main driving forces in modern biology. By allowing the simultaneous monitoring of the expression of the entire genome for a given...
Ioannis P. Androulakis