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» Challenges of component-based development
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145
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BMCBI
2008
113views more  BMCBI 2008»
15 years 2 months ago
SNPFile - A software library and file format for large scale association mapping and population genetics studies
Background: High-throughput genotyping technology has enabled cost effective typing of thousands of individuals in hundred of thousands of markers for use in genome wide studies. ...
Jesper Nielsen, Thomas Mailund
BMCBI
2010
167views more  BMCBI 2010»
15 years 2 months ago
Bi-directional gene set enrichment and canonical correlation analysis identify key diet-sensitive pathways and biomarkers of met
Background: Currently, a number of bioinformatics methods are available to generate appropriate lists of genes from a microarray experiment. While these lists represent an accurat...
Melissa J. Morine, Jolene McMonagle, Sinead Toomey...
117
Voted
BMCBI
2007
168views more  BMCBI 2007»
15 years 2 months ago
Benchmarking consensus model quality assessment for protein fold recognition
Background: Selecting the highest quality 3D model of a protein structure from a number of alternatives remains an important challenge in the field of structural bioinformatics. M...
Liam J. McGuffin
120
Voted
BMCBI
2008
242views more  BMCBI 2008»
15 years 2 months ago
annot8r: GO, EC and KEGG annotation of EST datasets
Background: The expressed sequence tag (EST) methodology is an attractive option for the generation of sequence data for species for which no completely sequenced genome is availa...
Ralf Schmid, Mark L. Blaxter
134
Voted
BMCBI
2007
136views more  BMCBI 2007»
15 years 2 months ago
Reduced modeling of signal transduction - a modular approach
Background: Combinatorial complexity is a challenging problem in detailed and mechanistic mathematical modeling of signal transduction. This subject has been discussed intensively...
Markus Koschorreck, Holger Conzelmann, Sybille Ebe...