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» Challenges of sequencing human genomes
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BIOCOMP
2006
13 years 10 months ago
Finishing Repetitive Regions Automatically with Dupfinisher
Currently, the genome sequencing community is producing shotgun sequence data at a very high rate, but genome finishing is not keeping pace, even with the help from several automa...
Cliff Han, Patrick Chain
NAR
2006
142views more  NAR 2006»
13 years 8 months ago
miRNAMap: genomic maps of microRNA genes and their target genes in mammalian genomes
Recent work has demonstrated that microRNAs (miRNAs) are involved in critical biological processes by suppressing the translation of coding genes. This work develops an integrated...
Paul Wei-Che Hsu, Hsien-Da Huang, Sheng-Da Hsu, Li...
BMCBI
2005
115views more  BMCBI 2005»
13 years 8 months ago
MPrime: efficient large scale multiple primer and oligonucleotide design for customized gene microarrays
Background: Enhancements in sequencing technology have recently yielded assemblies of large genomes including rat, mouse, human, fruit fly, and zebrafish. The availability of larg...
Eric C. Rouchka, Abdelnaby Khalyfa, Nigel G. F. Co...
ICPADS
2005
IEEE
14 years 2 months ago
Exploiting Multi-level Parallelism for Homology Search using General Purpose Processors
New biological experimental techniques are continuing to generate large amounts of data using DNA, RNA, human genome and protein sequences. The quantity and quality of data from t...
Xiandong Meng, Vipin Chaudhary
BMCBI
2004
140views more  BMCBI 2004»
13 years 8 months ago
What can we learn from noncoding regions of similarity between genomes?
Background: In addition to known protein-coding genes, large amounts of apparently non-coding sequence are conserved between the human and mouse genomes. It seems reasonable to as...
Thomas A. Down, Tim J. P. Hubbard