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» Challenges of sequencing human genomes
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BMCBI
2010
155views more  BMCBI 2010»
13 years 9 months ago
BISMA - Fast and accurate bisulfite sequencing data analysis of individual clones from unique and repetitive sequences
Background: Bisulfite sequencing is a popular method to analyze DNA methylation patterns at high resolution. A region of interest is targeted by PCR and about 20-50 subcloned DNA ...
Christian Rohde, Yingying Zhang, Richard Reinhardt...
JACM
2002
94views more  JACM 2002»
13 years 8 months ago
The greedy path-merging algorithm for contig scaffolding
Given a collection of contigs and mate-pairs. The Contig Scaffolding Problem is to order and orientate the given contigs in a manner that is consistent with as many mate-pairs as p...
Daniel H. Huson, Knut Reinert, Eugene W. Myers
DMTCS
2003
99views Mathematics» more  DMTCS 2003»
13 years 10 months ago
Combinatorial Problems Arising in SNP and Haplotype Analysis
It is widely anticipated that the study of variation in the human genome will provide a means of predicting risk of a variety of complex diseases. This paper presents a number of a...
Bjarni V. Halldórsson, Vineet Bafna, Nathan...
GCB
2006
Springer
140views Biometrics» more  GCB 2006»
14 years 15 days ago
PALMA: Perfect Alignments using Large Margin Algorithms
: Despite many years of research on how to properly align sequences in the presence of sequencing errors, alternative splicing and micro-exons, the correct alignment of mRNA sequen...
Gunnar Rätsch, Bettina Hepp, Uta Schulze, Che...
PRIB
2009
Springer
113views Bioinformatics» more  PRIB 2009»
14 years 3 months ago
c-GAMMA: Comparative Genome Analysis of Molecular Markers
Discovery of molecular markers for efficient identification of living organisms remains a challenge of high interest. The diversity of species can now be observed in details with ...
Pierre Peterlongo, Jacques Nicolas, Dominique Lave...